A major challenge in the race to bring innovative treatments, therapies and cures to market is that many of the drugs now being developed, including those using cannabis oil, are highly water-insoluble and exhibit poor bioavailability. A solution is to create nanoemulsions, also known as submicron emulsions or mini-emulsions. These non-toxic, liquid oil-in-water or water-in-oil formulations produce tiny droplets (50-1000 nm) that are generally recognized by the FDA as safe for human consumption, skin penetration, eye application, etc.
But to create viable products, you need scalable processing equipment that consistently and uniformly produces nano-sized particles and distributes them evenly in the nanoemulsion. Dyhydromatics gives you that competitive advantage.
Dyhydromatics ShearJet processors make it easy to fabricate highly stable nanoemulsions batch after batch. As the initial macroemulsion flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform, highly stable, precisely-sized nano-droplets without using solvents or surfactants. Fewer passes reduce your processing time costs. Plus, the uniformity of the nano-particles allows you to sterile-filter your nanoemulsions which can significantly lower your sterilizing expenses.
The ShearJet processors are designed to overcome several other nanoemulsion production challenges. Each comes with a simple-feed, jacketed, helicoil heat exchanger that reduces temperatures that trigger denaturing or damage to the microemulsions. You will never have to refill equipment ice compartments during the process again. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple medicines in multiple rooms daily. Simply move the processor from room to room.
To choose the right ShearJet for your nanoemulsion applications, sign up for a FREE day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.
If you are charged with overseeing cell disruption at your facility, one of your biggest challenges is acquiring equipment that gently ruptures the highest number of cells so you can harvest the greatest amount of soluble protein, enzymes, etc. Typically, as you increase the rupture rates you also increase processing temperatures and/or pressure levels during cell lysing. These higher temperatures and pressure levels can damage or denature the sought-after cellular contents costing you valuable time and wasted product.
Now there is a scalable solution for your pharmaceutical cell lysing applications.
With Dyhydromatics ShearJet processors you can consistently achieve cell rupture rates of 99%-plus and harvest more valuable cell material from tough to rupture mammalian, yeast, bacterial (E. coli) and algae cells. As the cells flow through the ShearJet Diamond Reaction Chamber, each experiences the same high shear rates. The resulting large cell membrane fragments make it easier to separate the cell products from the debris downstream than with a French press, mortar and pestle or other brands of high-pressure homogenizers. The ShearJet processing seldom changes the viscosity of the solution, a problem that also occurs when using other cell lysing equipment or techniques.
Each Dyhydromatics processor comes with a simple feed, helicoil heat exchanger that effectively cools the product in the Diamond Reaction Chamber so there is little to no damage or denaturing of the proteins, etc. You will never have to use ice to chill your lysing process again. This, plus fewer passes through the chamber, gives you tighter control over the pressure levels, temperature and shearing forces that impact the quality of your harvested cell products.
The ShearJet’s pharma-grade parts are easy to clean between runs which helps you meet the most stringent cGMP sanitation protocols. Also, you will find the portable HL60 processor is an economical solution when your daily schedule demands lysing multiple types of cells in multiple rooms. Just put the processor on a cart and move it throughout your facility.
To find the right ShearJet for your cell disruption applications, sign up for our FREE day of testing at +1 978 461 0200. Soon, you will be improving your cell disruption and harvesting for years.
Using liposomes for new drug delivery systems is an exciting area of research and manufacturing in the pharmaceutical industry. These artificially-created microscopic and spherical cells give drugs a greater therapeutic index, longer duration and increased frequency of delivery. But whether you are producing liposomes to stealthily target chemotherapeutic drugs, antifungal agents or coronavirus vaccine adjuvants, one of your challenges is to minimize the volume and cost of solvents as you scale up production.
Dyhydromatics ShearJet processors typically do not require solvents to produce high-quality liposomes. That means you can spend less on solvents (and less time removing them) when you scale up your production with these high shear processors.
At all production levels, the ShearJet’s Diamond Reaction Chamber applies the same high-shear rate to every mL. This allows you to consistently produce high quality, uniform, nano-sized liposomes in the quantities you want. Each ShearJet model comes with a simple feed, helicoil heat exchanger that effectively cools your product in the Diamond Reaction Chamber so there is little-to-no denaturing or damage to your liposomes and therapeutic agents. This, plus fewer passes through the chamber, gives you tighter control over the pressure levels, temperature and shearing forces batch after batch.
The ShearJet’s pharma-grade parts are easy to clean between runs so you can meet some of the most stringent cGMP sanitation protocols. Also, the portability of the HL60 processor makes it an economical addition to your facilities. You simply move it from room to room as you make multiple types of liposomes throughout the day.
To learn how easily and effectively you can scale up your liposome production, arrange for a FREE day of testing at +1 978 461 0200. Soon, you will be producing higher quality liposomes for years.