Personal Care / Cosmeceuticals Market

Liposomes

Liposomes,  spherical vesicles composed of phospholipids with aqueous core, found their application also in personal care. Some studies suggested that liposomes facilitate the passage of active ingredient across the outer layer the skin and transport them to the deep layers of the epidermis where they are absorbed and needed most. The localized drug depot in the skin, followed by sustained release of active compounds, improves the therapeutic index of the drug at the target site. Liposomes, suitable for loading hydrophilic as well as hydrophobic compounds, increase their stability and bioavailability. Increased skin hydration by film formation as well protects the skin from external factors, such as sun and temperatures. Nowadays liposomes are used in many cosmetic products, such as moisturizers, hair shampoos, creams, lotions, etc.

As such products are mostly produced in large amounts, one of the biggest challenges is finding ways to scale up your liposome production without using high volumes of expensive solvents in the process. Dyhydromatics ShearJet processors generate high-shear forces to the formulation and this is typically sufficient for production of high-quality liposomes. That means you can spend less on solvents (and less time removing them) when you scale up your production with these high shear processors. Moreover, our laboratory processors are directly scalable to our pilot/production scale processors due to its unique reaction chamber technology. 

At all production levels, the  Diamond Reaction Chamber applies the same high-shear rate to every mL. This allows you to consistently produce high quality, uniform, nano-sized liposomes in the quantities you want. Each ShearJet model comes with a simple feed, jacketed , helicoil heat exchanger that effectively cools your product in the Diamond Reaction Chamber, so there is little-to-no denaturing or damage to your liposomes and therapeutic agents. This, plus fewer passes through the chamber, gives you tighter control over the pressure levels, temperature and shearing forces batch after batch.

The ShearJet’s pharma-grade parts are easy to clean between runs so you can meet some of the most stringent cGMP sanitation protocols. Also, the portability of the HL60 processor makes it an economical addition to your facilities. You simply move it from room to room as you make multiple types of liposomes throughout the day. 

To learn how easily and effectively you can scale up your liposome production, arrange for a FREE day of testing at +1 978 461 0200. Soon, you will be producing higher quality liposomes for years.

Nanoemulsions

Nanoemulsions for cosmetic use offer several advantages over other technologies (such as liposomes and higher sized-emulsions), including ease of manufacturing, controllable particle size, high-kinetic stability using relatively little surfactant and many delivery options such as sprays, fluids, creams and foams. The efficient cosmetic product is defined by the textural properties and their ability to carry functional active ingredients. As nanoemulsions contain oil and water, lipophilic, hydrophilic and amphiphilic components can be incorporated. Small droplet size with a large surface-to-volume ratio enhances the penetration and permeability of the active ingredient into the skin and deposition on the hair. Topical application of nanoemulsion results in a thin lipid film, ensuring higher performance and bioavailability, however, the formulation can be delivered also as sprays, fluids and foams. But to create viable products, you need scalable processing equipment that consistently and uniformly produces nano-sized particles and distributes them evenly in the nanoemulsion. Dyhydromatics gives you that competitive advantage. Our laboratory processors are directly scalable to our pilot/production scale processors due to its unique reaction chamber technology. 

Dyhydromatics ShearJet processors make it easy to fabricate highly stable nanoemulsions batch after batch. As the initial macroemulsion flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform and precisely-sized nano-droplets achieved in fewer passes, which reduces your processing time and  costs. Plus, the uniformity of the nano-particles allows you to sterile-filter your nanoemulsions, which can significantly lower your sterilizing expenses and offers the possibility for development of preservative-free products.The ShearJet processors are designed to overcome several other nanoemulsion production challenges. Each comes with a simple-feed, jacketed, helicoil heat exchanger which  reduces temperatures that may  trigger denaturing or damage to the microemulsions. You will never have to refill equipment ice compartments during the process again. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple medicines in multiple rooms daily. Simply move the processor from room to room.

To choose the right ShearJet for your nanoemulsion applications, sign up for a FREE day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.

Nanoencapsulations 

Nanoencapsulation of certain therapeutic ingredients may have a major effect on cosmetic sensory properties of a cosmetic product. The spreadability, stickiness, oiliness and odor are important factors directly impacting the treatment adherence. For example, lipoic acid is an antioxidant in cosmetic industry, used for treatment and prevention of skin aging. As the lipoic acid contains sulfur, the cream with free fatty acid would have sulfuric smell. Free fatty acids would contribute to the stickiness and oiliness of the cream. On the other hand, the nanoencapsulated lipoic acid would mask the sulfuric smell and due to the large surface of the “lipid nanoparticles” the cream would spread nicer, creating a thin lipid film, improving antioxidant bioavailability and its performance.

If you are interested in scalable processing equipment that consistently and uniformly produces nano-sized particles, you came to the right place. Dyhydromatics gives you that competitive advantage. Our laboratory processors are directly scalable to our pilot/production scale processors due to its unique reaction chamber technology.

Dyhydromatics ShearJet processors make it easy to fabricate nanoparticles batch after batch. As the initial pre-processed formulation flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform, precisely-sized nano-droplets that can be achieved in fewer passes, which reduces your processing time and costs.

The ShearJet processors are designed to overcome several other production challenges. Each of the ShearJet processors comes with a simple-feed, jacketed, helicoil heat exchanger, which reduces the temperature that may trigger denaturing or damage to the molecules. You will never have to refill equipment ice compartments during the process again and you will also spare valuable time. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple formulations on different locations. Simply move the processor from room to room.

To choose the right ShearJet for your nanoencapsulation applications, sign up for a FREE day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.

Polysaccharide Nanoparticles 

Polysaccharides found their application in every single industry due to their therapeutic as well recommended dietary advantages. Naturally-derived polysaccharides have been widely used in cosmetic products, bringing benefits as emulsion stabilizer, film former, binder, viscosity-increasing agent, rheology modifiers, and suspending agents, enabling development of stable formulations with pleasant sensorial properties. Additionally, polysaccharide-based formulations were shown to improve skin protection and hydration. As the formulations have to be prepared in the controlled environment in order to maintain the products՚ quality, a certain polysaccharide particle size have to be achieved. Moreover, a high shear homogenization step in some cases even improves polysaccharide interaction with certain proteins, and consequently the stability of the formulation.

To create viable products, you need scalable processing equipment that consistently and uniformly produces nano-sized particles. Dyhydromatics gives you that competitive advantage. Our laboratory processors are directly scalable to our pilot/production scale processors due to its unique reaction chamber technology.

Dyhydromatics ShearJet processors make it easy to fabricate nano-sized polysaccharide fragments batch after batch. As the initial pre-processed polysaccharide formulation flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform, precisely-sized nano-droplets that can be achieved in fewer passes, which reduces your processing time and costs.

The ShearJet processors are designed to overcome several other production challenges. Each of the ShearJet processors comes with a simple-feed, jacketed, helicoil heat exchanger, which reduces the temperature of a sample gained due to high pressure and high velocities. You will never have to refill equipment ice compartments during the process again and you will also spare valuable time. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple formulations on different locations. Simply move the processor from room to room.

To choose the right ShearJet for your polysaccharide applications, sign up for a FREE day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.

Corporate Headquarters

63 Great Road, Suite 103

Maynard, MA 01754 USA

Phone: +1978 461 0200

Fax: +1 978 461 0201

European Headquarters

Kelterstrasse 9,

75236 Kaempfelbach, Germany

Phone +49 7231 1674048

Dyhydromatics, India
A-7, Mangal Society, Shreenagar
Wagle Estate, Thane (W) - 400604, India
Phone +91 77381 42553

  • LinkedIn
  • Facebook - White Circle

© 2015-present Dyhydromatics LLC. All rights reserved.

Legal