Nanoemulsions

In whatever way you are using nanoemulsions in your product development, these non-toxic, liquid oil-in-water or water-in-oil emulsions are changing how we get nutrients to plants, distribute coloring to foods, encapsulate enzymes in stain removal detergents, target drug therapies to cancer tumors and so much more.

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But what is the best equipment for making nanoemulsions? Is there a reliable processor that consistently reduces particles to uniform nano-size and distributes them evenly through the emulsion to improve stability?  Is there an equipment line that will let you seamlessly scale up as demand for your product increases?

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With Dyhydromatics processors you can take your high-quality nanoemulsion production to the next level and the next and the next.

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Fabricating nanoemulsions is faster, easier and more reliable with Dyhydromatics ShearJet processors. As the initial macroemulsion flows through the Diamond Reaction Chamber, each mL experiences the same high shear rates. This allows you to reliably reproduce uniform, highly stable, precisely-sized nano-droplets. Fewer passes reduce your processing time costs. And the uniformity of the nano-sized particles allows you to sterile-filter your nanoemulsions which can significantly lower your sterilizing expenses, too.

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Each ShearJet model comes with a simple-feed, jacketed, helicoil heat exchanger. It reduces processing temperatures that can denature or damage your microemulsions so there is less waste of valuable formulations. You will never have to use ice to chill your microemulsion processes again. The pharma-grade parts are easy to clean between runs which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor is an economical solution for making multiple batches in multiple compounding rooms daily.

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To choose the right ShearJet processor for your nanoemulsion applications, contact us for a day of testing at +1 978 461 0200. You will soon see how easily you can improve your nanoemulsion production for years.

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Cell Disruption

One of the biggest challenges you face is finding equipment that gently ruptures the maximum number of cells so you can harvest the greatest amount of soluble protein and sought-after cell products. Typically, when you increase the rupture rates you also increase processing temperatures and/or pressure levels during cell lysing. These higher temperatures and pressure levels can damage or denature proteins, enzymes, etc., costing you valuable time and wasted product.

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Now there is a scalable solution for your cell lysing applications.

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With Dyhydromatics ShearJet processors you can achieve cell rupture rates of 99%-plus and harvest more usable cell material from tough to rupture mammalian, yeast, bacterial (E. coli) and algae cells. As the cells flow through the Diamond Reaction Chamber, each experiences the same high shear rates. The resulting large cell membrane fragments make it easier to separate the sought-after cell products from the debris downstream than with a French press, mortar and pestle or high-pressure homogenizers. The ShearJet processing seldom changes the viscosity of the solution, a problem that also occurs when using other cell lysing equipment and techniques.

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Each Dyhydromatics processor includes a simple feed, helicoil heat exchanger that effectively cools the product in the Diamond Reaction Chamber so there is little to no damage or denaturing of the proteins, etc. You will never need to use ice during the lysing process again. This, plus fewer passes through the chamber, gives you tighter control over the pressure levels, temperature and shearing forces that impact the quality of your harvested cell products.

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The pharma-grade parts are easy to clean between runs so you can meet some of the most stringent cGMP sanitation protocols. Also, you will find the portable HL60 processor is an economical solution for disrupting multiple types of cells in multiple rooms throughout the day. Just load the processor on a cart and move it to where it is needed next.

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To find the right ShearJet processor for your cell disruption applications, sign up for our day of testing at +1 978 461 0200. Soon, you will be improving your cell disruption and harvesting for years.

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Liposomes

Using liposomes for delivery systems is an exciting and expanding area of research and development in biotechnology applications. Liposomes can be used in agriculture for delivering active ingredients such as nutritional supplements or pesticides to the fully grown plants. In textile industry, liposomes are of major interest for wool dying, durable fragrance, protective textile, e.g., wound dressing protection, just to name a few. Wool dying using liposomes is eco-friendly process, improving the textile quality with lower environmental impacts. But one of your biggest challenges is finding ways to scale up your liposome production without using high volumes of expensive solvents in the process. 

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Dyhydromatics ShearJet processors typically do not require solvents to produce high-quality liposomes. That means you can spend less on solvents (and less time removing them) when you scale up with these high shear processors.

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At all production levels, the Dyhydromatics Diamond Reaction Chamber applies the same high-shear rate to every mL. This allows you to consistently produce high quality, uniform, nano-sized liposomes in the quantities you want. Each ShearJet model comes with a simple feed, helicoil heat exchanger that effectively cools your product in the Diamond Reaction Chamber so there is little-to-no denaturing or damage to your liposomes and therapeutic agents. This, plus fewer passes through the chamber, gives you tighter control over the pressure levels, temperature and shearing forces batch after batch.

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The pharma-grade parts are easy to clean between runs which helps you meet some of the most stringent cGMP sanitation protocols. Also, the portability of the HL60 processor makes it an economical addition to your facilities. You simply move it from room to room as you make multiple types of liposomes throughout the day. 

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To learn how easily and effectively you can scale up your liposome production, arrange for a day of testing at +1 978 461 0200. Soon, you will be producing higher quality liposomes for years.

 

Polysaccharide Biotechnology

Polysaccharides are naturally occurring macromolecules and the most abundant polymers on earth. Pneumococci bacterium expresses chains of 1 of 92 immunologically distinct polysaccharide subunits anchored to the cell wall surface (capsule). The produced polysaccharide protects bacteria from complement-mediated opsonophagocytosis, the main mechanism of clearance of pneumococci from the lung. As it is essential for their colonization and virulence, it is widely used as a target antigen for production of vaccines. The pneumococcal polysaccharide vaccines usually consist of a mixture of most prevalent capsular serotypes in certain area as they vary greatly among continents.

If you are interested in scalable processing equipment that consistently reduces the polysaccharide chain size and uniformly produces nano-sized fragments, you came to the right place. Dyhydromatics gives you that competitive advantage. Dyhydromatics Reaction Chambers are made of diamond, which extends their lifespan compared to reaction chambers made of ceramics. They are available in different sizes and can be multi-slotted, which ensures that the process developed with a single-slotted Reaction Chamber is scalable.

Dyhydromatics ShearJet processors make it easy to reduce the particle size batch after batch. As the initial pre-processed formulation flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform, precisely-sized nanoparticles that can be achieved in fewer passes, which reduces your processing time costs.

 

The ShearJet processors are designed to overcome several other production challenges. Each of the ShearJet processors comes with a simple-feed, jacketed, helicoil heat exchanger that reduces the temperature that trigger denaturing or damage to the molecules. You will never have to refill equipment ice compartments during the process again and you will also spare valuable time. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple formulations on different locations. Simply move the processor from room to room.

 

To choose the right ShearJet for your polysaccharide applications, sign up for a FREE day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.

 

Gene Therapy Biotechnology

Gene therapy saves or at least improves many lives of individuals suffering from genetic disorders, viral infections and cancers. The groundbreaking CRISPR-Cas9 gene editing technology and RNA interference (RNAi) technology are gaining importance in treating such medical conditions. In RNAi technology, small interfering RNA (siRNA) molecule interferes with the expression of its target protein, and so silences the genes. To realize the potential of RNAi-based therapeutics, safe and efficient delivery is needed to transport non-coding RNAs to their site of action with minimal adverse effects and the nanoparticles are the most common choice. Solid lipid nanoparticles (SLNs), biocompatible and biodegradable polymer-based nanoparticles or lipid-polymer hybrid nanoparticles are a few examples of materials used for encapsulation and delivery of those gene therapeutics. Their nano-size is a key feature required for their systematic administration.

 

If you are interested in scalable processing equipment that consistently reduces the particles size and uniformly produces nano-sized encapsulations, you came to the right place. Dyhydromatics gives you that competitive advantage. Dyhydromatics Reaction Chambers are made of diamond, which extends their lifespan compared to reaction chambers made of ceramics. They are available in different sizes and can be multi-slotted, which ensures that the process developed with a single-slotted Reaction Chamber is scalable.

 

Dyhydromatics ShearJet processors make it easy to fabricate nano-sized particles batch after batch. As the initial pre-processed formulation flows through the ShearJet Diamond Reaction Chamber, each mL experiences the same high shear rates. This produces uniform, precisely-sized nanoparticles that can be achieved in fewer passes, which reduces your processing time costs.

 

The ShearJet processors are designed to overcome several other production challenges. Each of the ShearJet processors comes with a simple-feed, jacketed, helicoil heat exchanger that reduces the temperature that trigger denaturing or damage to the molecules. You will never have to refill equipment ice compartments during the process again and you will also spare valuable time. The ShearJet’s pharma-grade parts are easy to clean between batches which helps you meet the most stringent cGMP sanitation protocols. Plus, the portability of the HL60 processor makes it an economical solution when producing multiple formulations on different locations. Simply move the processor from room to room.

 

To choose the right ShearJet for your nanoencapsulation applications, sign up for a day of testing at +1 978 461 0200. You will see how easily Dyhydromatics processors will improve your operations for years.

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